| 31 May 1981 | First Round | Old Wellingtonians v Sherborne Pilgrims | Wellington College, Crowthorne | Results |
| 07 Jun 1981 | First Round (Replay) | Bradfield Waifs v Repton Pilgrims | Bradfield College, Reading | Results |
| 31 May 1981 | First Round | Downside Wanderers v Old Wykehamists | Downside School, Stratton-on-the-Fosse | Results |
| 31 May 1981 | First Round | Old Amplefordians v Shrewsbury Saracens | Ampleforth College, Ampleforth | Results |
| 31 May 1981 | First Round | Lancing Rovers v Felsted Robins | Lancing College Ground, Lancing | Results |
| 07 Jun 1981 | First Round | Stowe Templars v Old Cliftonians | Stowe School Ground, Stowe | Results |
| 07 Jun 1981 | First Round | Haileybury Hermits v Old Alleynians | Haileybury College Ground, Hertford | Results |
| 31 May 1981 | First Round | Eton Ramblers v Old Merchant Taylors | Agar's Plough, Eton College | Results |
| 31 May 1981 | First Round | Old Westminsters v Oundle Rovers | Vincent Square, Westminster | Results |
| 31 May 1981 | First Round | Old Cheltonians v Old Tonbridgians | College Ground, Cheltenham | Results |
| 31 May 1981 | First Round | Charterhouse Friars v Old Brightonians | Charterhouse School, Godalming | Results |
| 31 May 1981 | First Round | Marlborough Blues v Old Malvernians | Marlborough College Ground, Marlborough | Results |
| 31 May 1981 | First Round | Uppingham Rovers v Rugby Meteors | Middle Field Pitch 1, Uppingham School | Results |
| 31 May 1981 | First Round | Radley Rangers v Old Whitgiftians | Radley College Bigside Ground, Abingdon | Results |
| 31 May 1981 | First Round | Old Blundellians v St Edward's Martyrs | Blundell's School, Tiverton | Results |
| 31 May 1981 | First Round | Harrow Wanderers v Old Cholmeleians | Harrow School Cricket Ground, Harrow-on-the-Hill | Results |
| 14 Jun 1981 | Second Round | Bradfield Waifs v Old Wykehamists | Bradfield College, Reading | Results |
| 14 Jun 1981 | Second Round | Old Amplefordians v Lancing Rovers | Ampleforth College, Ampleforth | Results |
| 14 Jun 1981 | Second Round | Stowe Templars v Old Alleynians | Stowe School Ground, Stowe | Results |
| 14 Jun 1981 | Second Round | Old Merchant Taylors v Oundle Rovers | Durrants Sports Ground, Croxley Green | Results |
| 14 Jun 1981 | Second Round | Old Tonbridgians v Charterhouse Friars | Tonbridge School Ground, Tonbridge | Results |
| 14 Jun 1981 | Second Round | Old Malvernians v Rugby Meteors | Malvern College Ground, Malvern | Results |
| 14 Jun 1981 | Second Round | Radley Rangers v Old Blundellians | Radley College Bigside Ground, Abingdon | Results |
| 14 Jun 1981 | Second Round | Harrow Wanderers v Old Wellingtonians | Harrow School Cricket Ground, Harrow-on-the-Hill | Results |
| 05 Jul 1981 | Quarter-Final | Old Wykehamists v Old Amplefordians | Ridding Field, Winchester | Results |
| 05 Jul 1981 | Quarter-Final | Old Alleynians v Oundle Rovers | Dulwich College Ground, Dulwich | Results |
| 05 Jul 1981 | Quarter-Final | Charterhouse Friars v Old Malvernians | Charterhouse School, Godalming | Results |
| 05 Jul 1981 | Quarter-Final | Radley Rangers v Harrow Wanderers | Radley College Bigside Ground, Abingdon | Results |
| 26 Jul 1981 | Semi-Final | Old Wykehamists v Oundle Rovers | Ridding Field, Winchester | Results |
| 26 Jul 1981 | Semi-Final | Charterhouse Friars v Harrow Wanderers | Charterhouse School, Godalming | Results |
| 16 Aug 1981 | Final | Charterhouse Friars v Old Wykehamists | Burton's Court, Chelsea | Results |
| 31 May 1981 | First Round | Repton Pilgrims v Bradfield Waifs | Repton School Ground, Repton | Results |
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